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(2021) conducted a meta-analysis that included seven randomized controlled trials with 404 patients, and determined that probiotics as adjunctive therapy to antidepressants significantly improved depressive symptoms (standardized mean difference [SMD] = 0.83, 95% CI: 0.491.17), but were not effective as stand-alone treatment (SMD = 0.02)

The selection of a three-times-weekly administration schedule accounted for preventing adverse effects of daily anesthesia, and potential localized irritation and toxicity within the nasal mucosa [41, 47]

Health history: mention pancreatitis, gallbladder disease, kidney problems, pregnancy, or eating disorders

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