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1hr in phosphate-buffered saline followed by 24 hrs in growth medium) also triggered early stress signaling pathways, including p38 MAPK activation, Hsp27 phosphorylation, and eIF2 phosphorylation

Transcriptome profiling reveals dysregulation of inflammatory and protein synthesis genes in PCOS

In addition to mitochondrial OxS (as detailed below), there are numerous sources of endogenous OxS (e.g., inflammatory responses) that can be relevant to T2D progression [87]

Pharmacological dual incretin receptor agonist therapies utilize effects on glucagon secretion that are of clinical importance in antidiabetic regimens