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2015 Mar;54(2):251-63

A 2015 study on the subject concluded that compared to "gastroresistant tablets" of identical dosage (e.g., liposomal and branded forms), 250mg of orobuccal glutathione led to "much quicker absorption and a considerably higher bioavailability" while producing "rapid onset of action."21 Another 2015 study comparing sublingual and oral routes of administration found the sublingual group exhibited higher total and reduced glutathione levels in plasma

Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers

Meanwhile, an enzyme in the human body called glutathione reductase recycles oxidized glutathione back into its reduced state,18 allowing the tripeptide to continue carrying out its biochemical functions