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In other embodiments, the formulation or composition provides a therapeutically effective amount of at least one otic therapeutic agent at the site of disease with little or no detectable systemic exposure

It also confirms the limited effectiveness of carnitine supplementation

In DN renal tissues, mitochondrial accumulation due to dysfunction can be clearly observed, indicating that mitochondrial damage plays a significant role in ferroptosis during DN (143)

Lyophilized powder is typically favoured in laboratory settings because it allows precise reconstitution, flexible concentration ranges, and greater control over experimental variables