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Soluble macromolecules such as amino acids and monosaccharides up to 1,400 Da in size are able to readily cross this membrane via a channel that is permeable to both cations and anions ( The PVM in the related apicomplexan parasite, Toxoplasma gondii , has a similar exclusion limit for macromolecules to that of Plasmodium (Schwab et al., 1994), suggesting that related channels may exist to transport soluble macromolecules across their respective PVMs

That will require a larger trial with longer duration of treatmentit deserves a high priority given the current results

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A familiar example of this mechanism is insulin , a naturally occurring peptide produced by the pancreas