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Canonical Wnt/-catenin signaling pathway is activated via increased production of Wnt ligands by NTAPP To investigate whether NTAPP exposure affect a biological response via the canonical Wnt/-catenin signaling pathway, we treated hDP cells with two types of pharmacological inhibitor of Wnt/-catenin signaling, endo-IWR1 25 and IWP2 26 before NTAPP treatment

10.1371/journal.pone.0028378 [DOI] [PMC free article] [PubMed] [Google Scholar] Halliwell B

indica ) extract with skin brightening properties could also act through this mechanism, in addition to its inhibitory effect on tyrosinase [104, 105]