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Mast cells are the body's first responders, packed with inflammatory mediators like histamine

In fact, the concomitant action on three key metabolic pathways could be more effective in reducing body weight and in the treatment of obesity, promoting the reduction in food intake (GLP-1, glucagon), the increase in energy expenditure (glucagon) and in peripheral glucose uptake with potentiation of GLP-1-induced weight loss (GIP), mitigating the hyperglycemic effect of glucagon

These developments raised several questions, including concerns about the direct and indirect impacts of these anti-obesity drugs on bone metabolism, particularly in PwO experiencing a massive amount of weight loss

Exenatide in the treatment of diabetic patients with non-alcoholic steatohepatitis: a case series