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Opioid- induced tolerance and hyperalgesia

After TLR engagement, activated FLS produce chemokines (e.g., interleukin (IL)-8)/cytokines (e.g., IL-1, IL-6, and tumor necrosis factor (TNF)-), thereby recruiting and stimulating additional immune cells ( The role of synovial fibroblasts in the pathophysiology of OA crosstalk between synoviocytes and the innate immune system has been increasingly investigated in the past years