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Tirzepatide is FDA-approved for treating hyperglycemia (blood sugar that is too high), a symptom of type 2 diabetes

Although a large number of short-term and medium-term clinical studies support the safety and efficacy of GLP-1RAs, there are insufficient data on the presence of delayed side effects with their long-term (decades) use (Guirguis et al., 2024)

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Results announced in October 2025 demonstrated orforglipron's superiority on both HbA1c and weight endpoints, positioning it as a more effective second-line oral agent than existing oral diabetes medications