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Unlike the results found in previous studies, the effect of high dose N -acetylcysteine on air trapping and airway resistance of chronic obstructive pulmonary disease, a double-blinded, randomized, placebo-controlled trial (HIACE) conducted with 120 patients with stable COPD (58 treated with 600 mg of oral NAC twice a day and 62 with placebo), demonstrated a significant improvement in the function of the small airways, in addition to a reduction in the frequency of exacerbation of the disease [53]
Relevant to a discussion of GPx-1 in cancer, evidence from experimental mouse models suggests that, at least for some cancers, selenium is protective, in part, through GPx-1, although expression of other selenoproteins will be modulated by a range of dietary Se concentrations (98, 182)