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When a healthy person eats food, their digestive system breaks down carbohydrates into glucose, which enters their bloodstreamThis rise in blood sugar triggers the pancreas, an organ near your stomach, to release insulin into the bloodstream

Most critically, we lack direct evidence that GLP-1 agonists work through interoceptive mechanisms rather than through metabolic changes, altered gastric emptying, or other pathways

However, a systematic review of observational studies showed substantial heterogeneity in the results (Kirvalidze et al., 2022)