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Cost-effectiveness analyses for pharmacotherapy remain limited and are highly sensitive to assumptions about treatment duration and adherence

Clinicians should be cautious when prescribing semaglutide to individuals with underlying conditions and those receiving concomitant medications, and should ensure regular monitoring of kidney function after treatment initiation

These can be quite effective, he says, but very few patients end up taking part, for reasons that range from coverage and access challenges to inertia on the part of providers or patients