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A neurosurgical piston with a graduated force of 6066 g was placed over the exposed dura and left for 60 s to induce a compression injury

The absence or diminished function of ATP7B results in accumulation of copper in the hepatocyte due to both impaired copper excretion into bile and inability to incorporate copper into ceruloplasmin.14 The production of ceruloplasmin without attached copper (apoceruloplasmin), which has a shorter half-life than ceruloplasmin, results in decreased levels of ceruloplasmin in the blood of Wilsons patients

Garber AJ (2011) Long-acting glucagon-like peptide 1 receptor agonists: a review of their efficacy and tolerability

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