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A breach results in the release of apoptotic molecules, such as cytochrome c (CYCS), apoptosis-inducing factor mitochondria-associated 1 (AIFM1), and diablo IAP-binding mitochondrial protein (DIABLO/SMAC) [112]

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Glutathione synthesis can be impaired by cysteine depletion, protein-energy malnutrition, hyperglycemia, glucocorticoid at pharmacologic doses, and decreased secretion of anterior pituitary hormones (growth hormones, thyrotropin, gonadotropins), as often observed in prolonged critical illness

The sensitivity and 1specificity were then calculated for the approximate cutoff point