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Shared epigenetic mechanisms in depression-drug addiction comorbidity To better integrate these findings, we introduce a unifying three-axis framework, stress-response regulation, reward-circuit remodeling, and synaptic plasticity, which provides a coherent structure for understanding how epigenetic alterations converge across depression, drug addiction, and drug addiction-induced depression

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But thats the extent of data we have for the 104 week arm, everything else is 80 week data, so lets look at differences in weight loss in male vs female patients