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flavonoids including quercetin and epigallocatechin gallate modulate phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling, restricting proliferation and metabolic adaptation (Melim et al., 2022)
This approach frequently leads to chronic instability, recurrent injuries, and long-term dysfunction that could have been prevented with appropriate intervention during the initial healing window
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