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Additionally, a series of genes related to osteogenic differentiation ability were highly expressed in these cells during the process of osteogenic induction, including alkaline phosphatase ( Alp ), osteopontin ( Opn ), osterix ( Osx ), bone morphogenetic protein 2 ( Bmp2 ), runt-related transcription factor 2 ( Runx2 ) (Supplementary Fig

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The maximum studied cagrilintide dose in combination settings is 4.5 mg weekly