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In a follow-on study, general obese participants were administered either placebo or a dose-titrated regimen of MK-0493, in which participants received 400 mg PO QD of MK-0493 for seven days, with dose escalations of 200 mg every seven days until a final dose of 1000 mg PO QD was attained (48)

Context-Dependent Telomere Effects Recent work included breast-cancer-related cell lines and reported different telomere-maintenance responses between cellular models

Ethnic-group BMI adjustment for South Asian, Black African/Caribbean, Chinese/East Asian or Middle Eastern backgrounds, lower thresholds may apply (BMI 27.5+ without a condition, or 23+ with one), reflecting elevated metabolic risk at lower BMIs

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