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Calculation of sample size The first sample calculation was based on PON-1 activity levels reported by Menini et al

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Computational analysisscRNA data processing and reconstruction of context-specific metabolic models Prior to the reconstruction of single-cell metabolic models, scRNA datasets (Methods: scRNA Datasets) were downloaded from NCBIs Gene Expression Omnibus 89 for pre-processing with Seurat 90 and StanDep 20