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The P16 gene (cyclin-dependent kinase inhibitor 2A) located in the chromosome 9P21 region and serve as a key regulator in the cell cycle

[DOI] [PubMed] [Google Scholar] 26.Gutteridge J.M.C., Halliwell B

The results of several large randomized controlled trials indicated that maintaining blood glucose at near normal concentrations was the most important step in limiting the risk of diabetic neuropathy and lower extremity amputation (70-72)