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Phase I trial results (NCT05097911) have demonstrated that MTL-CEBPA has a good safety profile for the treatment of hepatocellular carcinoma and may enhance the therapeutic effects of tyrosine kinase inhibitors by modulating immune suppression

Indeed, GLS inhibitors have shown promising tumor-suppressive activities in preclinical models for 968 and bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES), or even in clinical models for CB-839 [100,101]