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A study in rats and mice found that semaglutide, a GLP-1 drug sold as Ozempic and Wegovy, may help curb alcohol consumption and reduce relapse-drinking behaviors

Semaglutide is known to reduce body weight, largely via appetite suppression, in patients with obesity 5,6 and in adult mouse models 30,31

Eli Lilly announced the topline results in December 2025: in obese participants with knee osteoarthritis, the 12 mg dose delivered a mean weight loss of 28,7% (32,3 kg / 71,2 lbs) at 68 weeks, and the 9 mg dose delivered a 26,4% reduction

Over time, uncontrolled high blood-sugar levels damage the nerves that control muscles in the stomach