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Two reviews of research studies showed that loss of fat mass with intermittent fasting is similar to continuous calorie-restricted diets (Cho et al

Reduces Hyperglycemia by Increasing Glucagon-Like Peptide 1 and Downregulates Systemic Inflammation (2022) This study enrolled 45 participants aged 40 to 70, who had fasting glucose levels between 110 and 150mg/dl

NRF2 influences the transcription of genes related to the electron transport chain (ETC) activating complexes II (succinate dehydrogenase) and IV (cytochrome oxidase) (Millichap et al., 2021

these were nonmutually exclusive such that an individual patient could be included in both if both an SGLT2i and GLP-1 RA were newly initiated during the study period