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Autophagy deficiency in renal proximal tubular cells leads to an increase in cellular injury and apoptosis under normal fed conditions

doi: 10.3390/ani13030494 10

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Ginsenoside Rg3 promotes the expression of multidrug resistance proteins (MRP) 1 and 3, activates Nrf2-mediated antioxidant gene expression, participates in detoxification, and reduces liver cytotoxicity ( Tanshinone IIA is isolated from Salvia miltiorrhiza Bunge [Lamiaceae] as a diterpene quinone ( in vitro and in vivo studies, tanshinone IIA pretreatment protects the liver from APAP-induced liver injury by activating Nrf2 and increasing the mRNA and protein levels of the Nrf2 target genes glutamate-cysteine ligase catalytic subunit (GCLC), NQO1, and HO-1 ( Andrographolide, a ladanditerpene extracted from Andrographis paniculata, is a MAPK/Nrf2 pathway activator ( in vivo and in vitro ( 2.3 Anthraquinones Rhein, an anthraquinone derivative of Rheum palmatum L