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Pharmacological management requires careful consideration in patients with diabetes: NSAIDs (such as ibuprofen or naproxen) are first-line when medication is needed and not contraindicated

Semaglutide GLP-1 is also approved for adults with a BMI of 30 kg/m or greater, regardless of whether they have weight-related medical conditions

doi: 10.1016/s0735-1097(99)00216-8

But there is room for both to exist. Sowa, in fact, sells a supplement called Balanced that features many of the same ingredients as the brands discussed above, including chromium and berberine, though she is clear that she does not consider it to be a substitute for a GLP-1 prescription