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They concluded that many other factors besides trauma influence the shape of the nail, including constricting footwear, snug-fitting stockings and hosiery, inadequate or inappropriate pedicures, and heritable traits that can lead to incurvation of the nail border, with subsequent inflammation and infection

Glutathione inhibits tyrosinase to prevent overproduction of melanin, and Vitamin C helps to restore glutathione to its active state and protects the skin from UV damage through oxidative stress

Data were normalized to -microglobulin and EGFP housekeeping genes (see Supplemental Methods) and are presented as a percentage of mRNA expression of the control siRNA

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