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DIO Gipr Syn/ and Glp1r Wnt1/ mouse studies Age-matched male Gipr fl/fl and Gipr Syn/ littermates were bred at Charles River Laboratories and shipped to Amgen at 79 weeks old, and age-matched Glp1r fl/fl and Glp1r Wnt1/ littermates were bred at Mount Sinai Hospital

In total, 86.4% of the semaglutide group lost a minimum of 5% of their body weight, with minimal adverse effects

The findings indicate that HFpEF is associated with various comorbidities, such as obesity, diabetes mellitus, and hypertension, which contribute to endothelial dysfunction

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