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In the context of ROS homeostasis, agents such as HIF stabilizers or inhibitors are often crucial for the adaptive survival of tissue cells under hypoxic conditions [559]

Similarly, Dings research team engineered a system linking two shRNA transcription plasmids targeting MDR-related genes (P-glycoprotein and survivin) to doxorubicin (DOX)-loaded DNA origami via disulfide bonds [57]

This paradigm explains the high prevalence of OA in non-weight-bearing joints (e.g., hands) among obese individuals, a finding that cannot be attributed to mechanical load alone