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N., Rehfeld, J

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

446 Studies suggest that for patients who respond poorly to mesalazine, sulfasalazine may provide an alternative that reduces inflammation and ulceration of the intestinal mucosa and possibly improves the local immune response

That would be the first downtick in a generation While the benefits to mortality and, by extension, life insurers may be apparent its important to consider how expensive these drugs will be in the short term