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(2021) proved that the pyroptosis-related proteins, NLRP3, caspase-1, and the N-terminal of gasdermin D (GSDMD-N), were reduced after lung inflation with 3% H 2 , which means H 2 alleviated lung I/R injury by inhibiting pyroptosis in Wistar rats

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Evidence indicates it may reduce treatment-related adverse effects and improve quality of life when used alongside conventional therapies, including in chronic inflammatory conditions and oncology settings, provided careful monitoring for drugnutrient interactions ( in vivo antioxidant, anti-inflammatory, immunomodulatory, antiviral, and anticancer effects

CAFs achieve this protective effect through several ways, including secretion of ferroptosis inhibitors, regulation of iron metabolism, and direct interaction with immunosuppressive cells (64)