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A recent review published in the National Library of Medicine underscores that rapid weight loss interventions can indeed exacerbate pre-existing psychological conditions or initiate new ones

Addressing sleep apnea (which weight loss often resolves) creates a positive feedback loop Exercise: Resistance training during GLP-1 therapy preserves muscle mass and improves body composition outcomes even when total weight loss is similar Hormonal factors (women): Perimenopausal hormonal changes affect how women respond to GLP-1 therapy

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Set realistic goals: Help patients set achievable weight loss and fitness goals that they can maintain in the long run