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In one preferred practice of the invention, one or more S-acyl glutathione derivatives is applied in admixture with the dermatologically acceptable carrier or vehicle (e.g., as a lotion, cream, ointment, soap, stick, or the like) so as to facilitate topical application and, in some cases, provide additional therapeutic effects as might be brought about, e.g., by moisturizing of the affected skin areas

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Mechanistic investigations revealed that exenatide stimulated -endorphin release from both spinal cord tissue and cultured primary microglia [24]

That being said, there has been, as you might expect, some very careful medicinal chemistry and pharmacologic work looking at what are the mechanisms where it can access parts of the brain