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The underlying mechanism generally consists of the oxidation of redox-reacting cysteine and/or tyrosine residues located within or near the active site, which creates intraprotein and interprotein bridges that affect protein function 8,9

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Mild thiamine deficiency in diabetics and improved post therapy thiamine status in clinical studies Mild thiamine deficiency has been observed in diabetics in different international studies.There is paucity of data on thiamine and thiamine dependant enzyme status in clinical diabetes mellitus

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