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Pattern: Symptoms worse outdoors or in the morning

The STEP trials assessed the efficacy and safety of semaglutide 2.4 mg in individuals with overweight (BMI 27.0 kg/m with at least one weight-related comorbidity) or obesity (BMI 30.0 kg/m), both with and without T2D or prediabetes

doi: 10.1016/j.biomaterials.2022.121687 205 MaGLiuZZhuCChenHKwokRTKZhangPet al

Exenatide (shown on the right, PDB 7LLL), which was the first GLP-1 receptor agonist approved by the FDA, shares just over 50% sequence identity with GLP-1, but has a similar structure and is able to activate the GLP-1 receptor, while avoiding rapid proteolytic degradation