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Different pathways addressing the same problem create more comprehensive inflammation control without the tissue-weakening effects of pharmaceutical anti-inflammatories

Here we review receptor biology and coactivator coupling, the pharmacology of SLU-PP-332 in cells and animals, dosing paradigms and route considerations used in published studies, translational biomarkers and experimental endpoints, context-dependent risks and unknowns, and practical guidance for nonclinical study design

Furthermore, the adequate activation of alternative pathways should occur along with the additional (direct) beneficial effects on affected targets