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As PD progresses, poor resolution, continuous peripheral immune noise, and -syn-driven cellular stress combine to alter the CNS milieu from adaptive neuroprotection to chronic neuroinflammation

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doi: 10.1124/mol.115.098509 82 DupinN.LecuyerH.CarlottiA.PoyartC.CoureuilM.ChanalJ.et al

To shed light on the interactions of the enzyme with the natural substrates, we docked flavan-3,3,4-triol ( 4 ) and flavan-3-on-4-ol ( 7 ) into the active pocket of the crystal structure of Pt GSTF8 obtained with ()-catechin ( 12 ) (Extended Data Fig