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A 2025 review by Jozwiak and colleagues surveys the peptides multifunctionality and possible medical applications (PMC11859134), and is a useful map of what has and has not been established

Genetic predispositions in metabolic and immune-relevant pathways can provide additional context for individualized risk assessment

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OVERDOSAGE There is no antidote for melatonin overdose, and significant toxicity is not expected to occur even after consumption of relatively large doses of it