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There is uncertainty about whether patients reporting this would be expected to clinically present and be diagnosed with diabetes, as well as the extent to which the avoidance of such progression commensurately avoids all important clinical sequelae, and this may introduce a risk of overestimation in terms of prevented diabetes. However, as a subclinical outcome, the relevance and importance to patients of maintaining blood sugars below the hyperglycemic range to avoid a formal diabetes diagnosis is likely to mean its inclusion in our analyses is a valid approach to capturing value

However, retatrutide introduced a few notable differences

And, although the amount of weight lost was statistically significant, the average loss was 2.4 pounds (1.1 kg), not necessarily clinically significant

The theoretical case for combination is straightforward