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How It Works (Step-by-Step) Complete the online health intake (no video visit required) Choose your plan: compounded semaglutide or branded tirzepatide Receive same-day prescription from a licensed provider Medication ships via one-day delivery with cold-chain packaging Begin app onboarding with AI coaching, behavior coaching, and meal plans Optional lab work through Labcorp or Quest (included, not required) Ongoing care team check-ins and dose adjustments as needed Geographic Availability Available in 46 states Not available in Alabama, Louisiana, or Mississippi Clinical Oversight and Safety LegitScript certified and HIPAA compliant Medical care through Your Big Picture Healthcare Pharmacy fulfillment through OptioRx Labs available through Labcorp and Quest (included, not required) In-app messaging for clinical questions with 24-hour response times Treatments Offered Weekly GLP-1 injections: compounded semaglutide

SUPPLEMENTARY FIGURE S11 qtPCR confirmation of selected genes determined to be altered by RNAseq analysis throughout manuscript

Oats, barley, apples, berries, Brussels sprouts, and carrots are excellent sources that require minimal preparation

Keep clinician communication ready