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Lets be honest about what we accept as normal in every other chronic disease

Drug expiry debate: the myth and the reality - African Health Science Assessment report: Ozempic - European Medicines Agency Exploring beyond numeric weight loss: The metabolic effects of semaglutide - Clinical nutrition ESPEN Expiration Dates - FDA Insulin Storage: A Critical Reappraisal - Journal of Diabetes Science & Technology Special Report: Potential Strategies for Addressing GLP-1 and Dual GLP-1/GIP Receptor Agonist Shortages - Clinical Diabetes, American Diabetes Association APIC position paper: Safe injection, infusion, and medication vial practices in health care - American Journal of Infection Control

The indirect comparison showed a mean difference of 6.4 kg (95% CI 11.2 to 1.7), with lower baseline weight in tirzepatide arms

None demonstrated increased rates of gastrointestinal malignancies compared to placebo