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503A does permit compounding of an FDA-approved drug if a change to the compounded product (such as dosage form) makes a significant difference for an individual patient, but 503A cannot be relied upon to produce essentially a copy of an approved drug or to compound a drug regularly or in inordinate amounts. Importantly, FDA has stated explicitly that a lower price does not constitute a significant difference for patients that would allow copies of approved drugs to be compounded

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However, education and support can ease this fear