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Parkinsons disease can affect movement, speech, and confidence, and supportive care may be strengthened through a functional medicine approach focused on oxidative stress, detoxification, and neurological resilience

The consistent observation of elevated circulating GLP-1 levels in the absence of a biological effect is a hallmark of GLP-1 resistance and analogous the incretin resistance reported in carriers of TCF7L2 T2D-risk alleles [43]

Semaglutide works for weight loss by mimicking the action of incretin, a natural gut hormone, particularly GLP-1, and targeting GLP-1 receptors in the brain that control appetite and slow down how quickly the stomach empties, making you feel fuller for longer

Thus, a physiological role has been proposed for Lp(a) in binding and transporting oxPL in the plasma (251)