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Reported Risks and Side Effects Gastrointestinal Issues: These may include nausea, vomiting, bloating, diarrhea, constipation, and slowed gastric emptying, which can sometimes lead to discomfort or changes in appetite

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[57] demonstrated that GLP-1 based agents were associated with a three-fold increased risk of pancreatic enzyme elevation relative to controls, yet did not indicate a significant rise in pancreatitis or pancreatic cancer

However, the two groups had no evidence of a difference in the composite incidence of MACE (HR 0.95