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This controlled copper transport serves as cofactor for critical enzymes including: Lysyl oxidase: Essential for collagen and elastin cross-linking Lysyl hydroxylase: Required for proper collagen synthesis Superoxide dismutase: Provides antioxidant defense mechanisms Cytochrome c oxidase: Powers cellular respiration Tyrosinase: Facilitates melanin production The peptide can readily obtain Cu from plasma albumin, functioning bidirectionally to transport copper into or out of cells based on cellular requirements

The nominated uses included chronic insomnia, narcolepsy and opioid withdrawal, with a proposed subcutaneous formulation

Brain 133 , 26262634 (2010)

There is also a Marcus No-Penalty CD with 7-month, 11-month, and 13-month terms, as well as a 20-month rate-bump CD