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In STEP 10, mean weight loss on Wegovy was 13.9% at 52 weeks, and 81% of participants returned to healthy blood sugar levels

One small study found no increased risk of major birth defects or miscarriage among women who took GLP-1 RAs during their first trimester

( C ) DTC-specific RNAi against hmr-1 extends the lifespan of WT worms (8.7% extension in median lifespan) but not that of glp-1 mutants

This includes: Measurement of resting heart rate and blood pressure Review of cardiovascular history, including arrhythmias, heart failure, or ischaemic heart disease Assessment of concurrent medications that may affect heart rate (e.g., beta-blockers, calcium channel blockers, digoxin) Evaluation of symptoms such as palpitations, chest pain, or dyspnoea During treatment , patients should be advised to monitor for symptoms that may indicate heart rate changes, such as palpitations, dizziness, or unusual fatigue