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The authorization number (UB-IACUC N06/2022) was given and the study was done also in conformation with the international regulation, minimizing the number of mice used and their suffering

282,283 These cells accumulate in the synovial membrane and subchondral bone, releasing pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which promote the degradation of joint cartilage and the inflammatory response

Clinical research supports the use of glutathione supplements in oral doses ranging from 501000 mg daily for long-term benefits

Older reports investigating methionine in relation to mental disease noted doses up to 10g per day not resulting in harm to patients (16)