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But the trade-off is better adherence: when patients tolerate their medication, they stick with it

440 ATP7B encodes a transmembrane copper transport ATPase, and mutations in ATP7B cause Wilsons disease by impairing copper homeostasis, leading to copper overload in the liver, brain, and other organs

Full reimbursement is likely to be unaffordable for most publicly funded healthcare systems in the short term, but a steady reduction in the threshold for reimbursement is believed to be inevitable in the medium to long term

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