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The creatures glucose-regulating system must therefore possess remarkable flexibility and, crucially, the hormonal signals that trigger insulin release must be extraordinarily durable

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Important attitude shift A roundup of expert opinions in the Journal of the American Medical Association (JAMA), has heralded the WHO guidelines as a necessary reframing of obesity from an issue of personal control to a complex disease with strong biological mechanisms

Those with clinically unusual, changing, or concerning features are biopsied