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4.3 Weight change 4.3.1 Uncontrolled studies While insulin monotherapy causes consistent weight gain, adding GLP-1RA leads to consistent weight loss

Two papers published in JAMA Neurology suggest that GLP-1 receptor agonists could have a neuroprotective effect, reducing the risk of dementia by up to 50%

Concerns about discontinuing AOMs Obesity, affecting over 2.2 billion adults globally in 2020 and projected to rise to 3.3 billion by 2035, is linked to significant health risks, including some cancers, cardiovascular disease, and type 2 diabetes