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Ferroptosis is a novel form of programmed cell death characterized by iron-dependent oxidative damage, lipid peroxidation, and the accumulation of reactive oxygen species (Zuo et al., 2022)

1 Clinically, NAC is probably best known as an antidote to paracetamol (acetaminophen) poisoning, but it is also used for a large variety of other indications, based on its antioxidant, anti-inflammatory and mucolytic effects

Altered DNA methylation patterns have been observed in patients with hypertension

The mechanism could be that DAPA binding to FPN led to the inhibition of ubiquitination degradation of FPN[163], which provided a new perspective for DAPA application in the treatment of DKD